![]() Salviati L: Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency. Myalgia and new-onset of type 2 diabetes have been associated with statin treatment, which both could be linked to reduced coenzyme Q10 (CoQ10) in skeletal. CoQ 10, as with all water-insoluble compounds (i.e., fat molecules), has been reported to be better absorbed in the intestines when administered after a meal containing fat. It is also used to monitor CoQ10 status in patients with mitochondrial cytopathies, patients receiving statin therapy, or during treatment of various degenerative conditions including Parkinson and Alzheimer diseases. Both doses, however, did improve CoQ10 blood status. CoQ 10 is a fat-soluble vitamin-like compound that is found throughout organ tissues, but particularly in the heart, skeletal muscle, liver, kidney, and brain. The researchers designed their study with a daily dose of 300 g of CoQ10, because their previous trial on 150 mg could not induce anti-inflammatory benefit. Although the evidence is conflicting regarding whether supplementing with CoQ10 relieves statin-induced muscle symptoms, many doctors recommend CoQ10. With their new findings reassuring them, the researchers state that CoQ10 appears intimately related to vitamin E because it “not only protects vitamin E against superoxide-driven oxidation, but also regenerates vitamin E during antioxidation processes.” It may also counteract adverse effects of statin medications. Markers of inflammation also improved, and vitamin E levels increased in proportion to increases in blood CoQ10. Coenzyme Q10 (CoQ10) has been linked to improved aging, exercise performance, heart health, diabetes, fertility and migraines. In as little as four weeks, CoQ10 levels increased five-fold in the supplemented group compared to placebo. Should patients on statins take Coenzyme Q10 supplementation to reduce the risk of statin-induced myopathy Prepared by UK Medicines Information (UKMi). To assess the effect of CoQ10 supplements on statin users, Taiwanese researchers recruited 51 statin users with coronary artery disease and assigned them to a daily CoQ10 supplement or placebo for 12 weeks. The body uses CoQ10 for energy and cell growth, and as an antioxidant. The objective of this study was to assess whether patients with statin-associated myalgia can be successfully treated with Coenzyme Q10 (CoQ10) to improve symptoms and maintain them on statin therapy. But more statin use may also mean more sales of coenzyme Q10 (CoQ10) supplements-because research continues to link statin therapy to low CoQ10 levels. Background and aims: Statin associated muscle symptoms are common and affect adherence to statin treatment. New cholesterol treatment guidelines proposed by the American Heart Association could very well double the amount of U.S.
0 Comments
Leave a Reply. |